PONDR® References

When using the VL-XT Predictor, please cite the following references:

Predicting protein disorder for N-, C-, and internal regions.
Li, X., P. Romero, M. Rani, A. K. Dunker, and Z. Obradovic, Genome Informatics, 1999, 10:30-40.

Sequence complexity of disordered protein.
Romero, P., Z. Obradovic, X. Li, E. Garner, C. Brown, and A. K. Dunker, Proteins: Struct. Funct. Gen., 2001, 42:38-48.

Sequence data analysis for long disordered regions prediction in the calcineurin family.
Romero, P., Z. Obradovic, and A. K. Dunker, Genome Informatics, 1997, 8:110-124.


When using the XL1 predictor, please cite the following reference:

Identifying Disordered Regions in Proteins from Amino Acid Sequences.
Romero, P., Z. Obradovic, C.R. Kissinger, J.E. Villafranca, and A.K. Dunker, Proc. I.E.E.E. International Conference on Neural Networks, 1997, p. 90-95.


When using the VL3 predictor, please cite the following reference:

Prediction of boundaries between intrinsically ordered and disordered protein regions.
Radivojac P, Obradovic Z, Brown CJ, Dunker AK., Pac. Symp. Biocomput. 2003, 8, 216-227.


When using the VSL1 predictor, please cite the following reference:

Exploiting heterogeneous sequence properties improves prediction of protein disorder.
Obradovic Z, Peng K, Vucetic S, Radivojac P, Dunker AK., Proteins. 2005,61 Suppl 7,176-82.


When using the DEPP predictor, please cite the following reference:

Intrinsic disorder and protein phosphorylation.
Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes JG, Obradovic Z, Dunker AK., Nuclear Acid Res. 2004, 32 (3), 1037-1049.


Other references:

Significance of protein disorder:

Intrinsically Disordered Protein.
Dunker, A. K., J. D. Lawson, C. J. Brown, P. Romero, J. S. Oh, C. J. Oldfield, A. M. Campen, C. M. Ratliff, K. W. Hipps, J. Ausio, M. S. Nissen, R. Reeves, C. H. Kang, C. R. Kissinger, R. W. Bailey, M. D. Griswold, W. Chiu, E. C. Garner, and Z. Obradovic, J. Mol. Graphics and Modeling 2001

Protein disorder and the evolution of molecular recognition: theory, predictions, and observations.
Dunker, A. K., E. Garner, S. Guilliot, P. Romero, K. Albrecht, J. Hart, Z. Obradovic, Pacific Symp. Biocomputing 1998, 3:473-484.

Thousands of proteins likely to have long disordered regions.
Romero, P., Z. Obradovic, C.R. Kissinger, J.E. Villafranca, S. Guilliot, E. Garner, A.K. Dunker, Pacific Symp. Biocomputing, 1998, 3:437-448.

Crystal structure of calsequestrin from rabbit skeletal muscle sarcoplasmic reticulum.
Wang, S., W.R. Trumble, C.R. Wesson, A.K. Dunker, C.H. Kang, Nat. Struct. Biol., 1998, 5:476-483.

On the importance of being disordered.
Dunker, A. K., Z. Obradovic, P. Romero, C. Kissinger, E. Villafrance, PDB Newsletter, 1997, 81:3-5.


Applications of PONDR®:

Identification of intrinsic order and disorder in the DNA damage-recognition protein XPA.
IaKoucheva, L. M., A. L. Kimzey, C. D. Masselon, J. E. Bruce, E. C. Garner, C. J.Brown, A. K. Dunker, R. D. Smith, E. J. Akerman. Protein Science, 2001, 10:560-571.

Instrinsic protein disorder in complete genomes.
Dunker, A. K., Z. Obradovic, P. Romero, E.C. Garner, C.J. Brown, Genome Informatics, 2000, 11:161-171.

Isolation and characterization of cDNAs expressed in the early staged of flavonol-induced pollen germination in petunia.
Guyon, V. N., J. D. Astwood, E. C. Garner, A. K. Dunker, L. P. Taylor, Plant Physiol., 2000, 123:699-710.

Analysis of clusterin structure by prediction plus protease.
Bailaey R. W., M.D. Griswold, E. Garner, P. Romero, Z.Obradovic, A.K. Dunker, Biophys., 1999, 76:A382.

Predicting Binding Regions within Disordered Proteins
Garner E., P. Romero, A.K. Dunker, C. Brown, Z. Obradovic, Genome Informatics, 1999, 10:41-50.

Predicting Disordered Regions from Amino Acid Sequence: Common themes Despite Differing Structural Characterization.
Garner, E., P. Cannon, P. Romero, Z. Obradovic, and A.K. Dunker, Genome Informatics, 1998, 9: 201-214.

Thousands of Proteins Likely to Have Long Disordered Regions.
Romero, P., Z. Obradovic, C.R. Kissinger, J.E. Villafranca, E. Garner, S. Guilliot and A.K. Dunker, Pacific Symposium on Biocomputing, 1998, 3:435-446.

Protein Disorder and the Evolution of Molecular Recognition: Theory, Predictions and Observations.
Dunker, A.K., E. Garner, S. Guilliot, P. Romero, K. Albrecht, J. Hart, Z. Obradovic, C. Kissinger, and J.E. Villafranca, Pacific Symposium on Biocomputing, 1998, 3:471-782.


Development of predictors of protein disorder:

Flavors of protein disorder.
Vucetic S, Brown CJ, Dunker AK, Obradovic Z. Proteins, 2003, 52: 573-584.

Prediction of boundaries between intrinsically ordered and disordered protein regions
Radivojac P, Obradovic Z, Brown CJ, Dunker AK. Pac. Symp. Biocomput., 2003, 8:216-227.

Intelligent data analysis for protein disorder prediction.
Romero P. Z., Obradovic C., Dunker A. K., Artificial Intelligence Reviews, 2001, 14(6): 447-484.

Sequence complexity of disordered protein.
Romero, P., Z. Obradovic, X. Li, E. C. Garner, C. J. Brown, A.K. Dunker. Proteins: Struc., Funct., Gen., 2001, 42:38-48.

The protein non-folding problem: amino acid determinants of intrinsic order and disorder.
Williams, R. M.,Z. Obradovic, V. Mathura, W. Braun, E. C. Garner, J. Young, S. Takayama, C. J. Brown, and A. K. Dunker. Biocomp., 2001 6:89-100.

Comparing predictors of disordered protein.
Li X., Obradovic Z., Brown C.J., Garner E. C., Dunker A.K., Genome Informatics, 2000, 11:172-184.

Predicting Protein Disorder for N-, C-, and Internal Regions
Li, X.,P. Romero, M. Rani, A. K. Dunker, and Z. Obradovic, Genome Informatics, 1999, 10:30-40.

The Sequence Attribute Method for Determining Relationships Between Sequence and Protein Disorder
Xie, Q., G. E. Arnold, P. Romero, Z. Obradovic, E. Garner, and A. K. Dunker, Genome Informatics Workshop, 1998, 9:193-201.

Sequence data analysis for long disordered regions prediction in the calcineurin family.
Romero, P., Z. Obradovic, and A.K. Dunker, Genome Informatics, 1997, 8:110-124.

Identifying Disordered Regions in Proteins from Amino Acid Sequences.
Romero, P., Z. Obradovic, C.R. Kissinger, J.E. Villafranca, and A.K. Dunker, Proc. I.E.E.E. International Conference on Neural Networks, 1997, 1:90-95.